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Klub Bechterevikov • Zobrazenie témy - Čo je to BIOLOGICKÁ LIEČBA
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Čo je to BIOLOGICKÁ LIEČBA

PoslaťNapísal: Ned 13. Mar 2011 20:37:27
od andilek
Čo je to Biologická liečba

Biologická liečba (cielená liečba) využíva obranyschopnosti organizmu k boju proti rakovine či niektorým autoimunitným chorobám vďaka tomu, že sú v súčastnej dobe lepšiee známe štruktúry a pochody na povrchu aj vo vnútri bunky. Na základe toho vedci nachádzajú také molekuly a pochody, ktoré sú typické iba pre bunky spojené s nádorovým alebo autoimunitným ochorením (reumatoidná artritída, Crohnova choroba atd.), a v bunkách normálnych tkanív sa buď nevyskytujú vôbec, alebo len v malej miere.

Liečivo v rámci tejto cielenej biologickej liečby pôsobí iba na tieto molekuly a pochody, zlepšujú alebo opravujú schopnosť sebaobrany organizmu, a aj keď ich sprevádza tiež rada nežiadúcich účinkov, v zrovnaní s klasickou liečbou je ich ďaleko menej a menej významných.

Napríklad chemoterapia je zameraná na bunkové štruktúry, ktoré sú spoločné všetkým bunkám v organizme. Okrem nádorových buniek pôsobí teda aj na bunky zdravých tkanív, ktoré ničí; kvôli tomu sa pri nej vyskytuje celá rada nežiadúcich účinkov.

Obrázok

Látky používané v biologickej liečbe sa nazývajú modifikátory imunitnej odpovede. Večšinou sú to látky, ktoré ľudské telo normálne vyrába. Pre účely cielenej liečby nádorov a autoimunitných chorôb sú však tieto látky vyrobené v laboratóriu a telu dodáváné. Niektoré typy biologickej liečby sa naopak podávajú k zníženiu nežiadúcich účinkov, ktoré môžu nastať po použití iných typov protinádorovej terapie.

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